By A Mystery Man Writer
This section provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain section contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function. More information about the specific content and the generation and analysis of the data in this section can be found on the Methods Summary. Learn about: Expression levels for all human proteins in regions and subregions of the human brain Expression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brain Brain enriched genes with higher expression in any of the regions of the brain compared to peripheral organs Regional enriched genes with higher expression in a single or few regions of the brain Cell-type and cell-compartment distribution of selected proteins in the human and mouse brain Differences in gene expression between mammalian species Additional information: In addition to the data provided in the brain section there is also data on human retina and single cell data containing information on protein expression in human neuronal and non-neuronal cell-types in the central nervous system.
Analysis of the Human Protein Atlas Image Classification
A Human Protein Atlas for Normal and Cancer Tissues Based on
Research article summary] First major analysis of Human Protein
Tissue-based map of the human proteome
Gene and Drug Landing Page Aggregator: (Gene)
Atlas of human brain blood vessels highlights changes in
Proteomic Atlas of the Human Brain in Alzheimer's Disease
Human Protein Atlas - Today ”An atlas of the protein-coding genes
JCI Insight - Identifying candidate genes for 2p15p16.1
Human 'Atlas' Reveals Where Proteins Reside in the Body
Evolution of the brain - Wikipedia
A region‐resolved proteomic map of the human brain enabled by high
The human proteome in mouse brain - The Human Protein Atlas